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Comfort Formula + Hemp Extract

$119.00

2oz bottle, 1500 mg or 25 mg per serving of Full Spectrum Hemp Extract
30 drops per serving (1 Dropper Full), 60 servings per bottle

Reduces acute, chronic, and neuropathic pain, supports natural anti-inflammatory action

Pain keeps you from living the best version of your life. It can be caused by various factors such as an overstimulated nervous system, muscle fiber breakdown, inflammation and anatomical changes as a bone fracture or joint degeneration from aging.

Regardless of the cause, living with pain makes day-to-day life difficult. Botanicals have pain-relieving and anti-inflammatory properties and can be helpful in treating headaches, insomnia, nerve pain, chronic pain and seizure disorders.

Proprietary blend

Full Spectrum Hemp Extract, 1500mg per bottle, plus:

  • Curcuma Longa (turmeric) root
  • Withania somnifaria (Ashwaghanda) root
  • Corydalis ambigua (Corydalis) rhizome
  • Glycyrrhiza glabra (Licorice) root
  • Theobroma Cacao (cacao) nibs
  • Vanilla Planifolia (vanilla) bean
  • Capsicum frutescens (Cayenne) fruit
  • Piper nigrum (Black pepper) fruit in a base of MCT oil

Out of stock (Available from: 2021-08-13)

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SKU: DHB52418 Category:
Benefits
  • Helps to modulate acute or chronic pain and supports natural anti-inflammatory action
  • Regardless of the cause, physical pain is difficult. Whether it stems from an over-stimulated nervous system, muscle fiber breakdown (read….overexercising), inflammation, and anatomical changes such as a bone fracture or degeneration of joints from aging, it has a deteriorative effect on virtually every aspect of our lives. Botanicals have pain-relieving and anti-inflammatory properties and can be helpful in treating headaches, insomnia, nerve pain, chronic pain and seizure disorders.
  • Curcuma Longa (turmeric) Has extensive Anti-inflammatory effects and pain reduction
  • Withania somnifaria (Ashwaghanda) Reduces pain in arthritic joints, Reduces Nerve pain and inflammation
  • Corydalis ambigua (Corydalis) Reduces intensity of pain due to anti-inflammatory effects
  • Glycyrrhiza glabra (Licorice) Reduction of pain in arthritis and period cramps due to anti-inflammatory effects
  • Theobroma Cacao (cacao) Has effective anti-inflammatory effects
  • Vanilla Planifolia (vanilla) Significant anti-inflammatory effects
  • Capsicum frutescens (Cayenne) Safely improves low back pain
  • Piper nigrum (Black pepper) Has significant pain reducing effects, promotes the absorption of Curcuma longa and Corydalis

Recommendations for Usage
Take 30-60 drops three times per day as needed for pain Store in a cool, dry place away from direct sunlight.

Highlights
Caution: Not for use during pregnancy or in children under 12 years old.

References
  1. Reducing oxidative stress on Liver. – Read More
  2. Anti-inflammatory effects of curcuma. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research [published correction appears in Altern Med Rev. 2009 Sep;14(3):277]. Altern Med Rev. 2009;14(2):141-153. – Read More
  3. Anti-inflammatory. Ammon HP, Wahl MA. Pharmacology of Curcuma longa. Planta Med. 1991;57(1):1-7. doi:10.1055/s-2006-960004. – Read More
  4. Bio-availability of crucumin improved with Piperine. Suresh D, Srinivasan K. Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats. Indian J Med Res. 2010;131:682-691. – Read More
  5. Curcuma reduces pain in knee OA. Henrotin Y, Malaise M, Wittoek R, et al. Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study. Arthritis Res Ther. 2019;21(1):179. Published 2019 Jul 27. doi:10.1186/s13075-019-1960-5. – Read More
  6. Curcuma effective in chron’s and colitis. Cunha Neto F, Marton LT, de Marqui SV, Lima TA, Barbalho SM. Curcuminoids from Curcuma Longa: New adjuvants for the treatment of crohn’s disease and ulcerative colitis?. Crit Rev Food Sci Nutr. 2019;59(13):2136-2143. doi:10.1080/10408398.2018.1456403. – Read More
  7. Curcuma improves non arthritic joint pain. Rao PS, Ramanjaneyulu YS, Prisk VR, Schurgers LJ. A Combination of Tamarindus indica seeds and Curcuma longa Rhizome Extracts Improves Knee Joint Function and Alleviates Pain in Non-Arthritic Adults Following Physical Activity. Int J Med Sci. 2019;16(6):845-853. Published 2019 Jun 2. doi:10.7150/ijms.32505. – Read More
  8. Curcuma alleviating neuropathic pain, especially in chronic pain. Moini Zanjani T, Ameli H, Labibi F, Sedaghat K, Sabetkasaei M. The Attenuation of Pain Behavior and Serum COX-2 Concentration by Curcumin in a Rat Model of Neuropathic Pain. Korean J Pain. 2014;27(3):246-252. doi:10.3344/kjp.2014.27.3.246. – Read More
  9. Curcuma as effective as Ibuprofen in OA knee pain with less GI side effects. Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, et al. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014;9:451-458. Published 2014 Mar 20. doi:10.2147/CIA.S58535. and neuropathic analgesic effects with Withania. Lim DW, Kim JG, Lim EY, Kim YT. Antihyperalgesic effects of ashwagandha (Withania somnifera root extract) in rat models of postoperative and neuropathic pain. Inflammopharmacology. 2018;26(1):207-215. doi:10.1007/s10787-017-0389-1. – Read More
  10. Rat model showed inflammation, chronic and acute pain decrease over time w withania. Shahraki MR, Samadi Noshahr Z, Ahmadvand H, Nakhaie A. Anti-nociceptive and anti-inflammatory effects of Withania somnifera root in fructose fed male rats. J Basic Clin Physiol Pharmacol. 2016;27(4):387-391. doi:10.1515/jbcpp-2015-0053. – Read More
  11. Withania reduced pain, stiffness and disability in knee pain. Ramakanth GS, Uday Kumar C, Kishan PV, Usharani P. A randomized, double blind placebo controlled study of efficacy and tolerability of Withaina somnifera extracts in knee joint pain. J Ayurveda Integr Med. 2016;7(3):151-157. doi:10.1016/j.jaim.2016.05.003. – Read More
  12. Anti-inflammatory effects Withathania. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev. 2000;5(4):334-346. – Read More
  13. Corydalis is shown to reduce acute, inflammatory and neuropathic pain. Wang L, Zhang Y, Wang Z, et al. The Antinociceptive Properties of the Corydalis yanhusuo Extract. PLoS One. 2016;11(9):e0162875. Published 2016 Sep 13. doi:10.1371/journal.pone.0162875. – Read More
  14. Corydalis reduced pain intensity and bothersomeness in cold induced pain. Yuan CS, Mehendale SR, Wang CZ, et al. Effects of Corydalis yanhusuo and Angelicae dahuricae on cold pressor-induced pain in humans: a controlled trial. J Clin Pharmacol. 2004;44(11):1323-1327. doi:10.1177/0091270004267809. – Read More
  15. Corydalis was effective in reduction of neuropathic pain. Choi JG, Kang SY, Kim JM, et al. Antinociceptive Effect of Cyperi rhizoma and Corydalis tuber Extracts on Neuropathic Pain in Rats. Korean J Physiol Pharmacol. 2012;16(6):387-392. doi:10.4196/kjpp.2012.16.6.387. – Read More
  16. Corydalis pain reduction related to anti-inflammatory molecules in the plant. Yin ZY, Li L, Chu SS, Sun Q, Ma ZL, Gu XP. Antinociceptive effects of dehydrocorydaline in mouse models of inflammatory pain involve the opioid receptor and inflammatory cytokines. Sci Rep. 2016;6:27129. Published 2016 Jun 7. doi:10.1038/srep27129. – Read More
  17. A review of the anti-inflammatory effects of licorice. Yang R, Yuan BC, Ma YS, Zhou S, Liu Y. The anti-inflammatory activity of licorice, a widely used Chinese herb. Pharm Biol. 2017;55(1):5-18. doi:10.1080/13880209.2016.1225775. – Read More
  18. Glycyrrhiza improves RA by decreasing inflammation. Chen H, Pan T, Liu P, Wang P, Xu S. Baihu Jia Guizhi Decoction Improves Rheumatoid Arthritis Inflammation by Regulating Succinate/SUCNR1 Metabolic Signaling Pathway. Evid Based Complement Alternat Med. 2019;2019:3258572. Published 2019 Dec 26. doi:10.1155/2019/3258572. . – Read More
  19. Anti-inflammatory effects in endometriosis. Wang XR, Hao HG, Chu L. Glycyrrhizin inhibits LPS-induced inflammatory mediator production in endometrial epithelial cells. Microb Pathog. 2017;109:110-113. doi:10.1016/j.micpath.2017.05.032. – Read More
  20. Pain reduction in dysmenorrhea compared to ibuprofen. Jafari Z, Emtiazy M, Sohrabvand F, et al. The effect of Glycyrrhiza glabra L. on Primary Dysmenorrhea compared with Ibuprofen: A Randomized, Triple-Blind Controlled Trial. Iran J Pharm Res. 2019;18(Suppl1):291-301. doi:10.22037/ijpr.2020.1100961. . – Read More
  21. Cacao in the modulation of inflammation in metabolic syndrome. Gu Y, Lambert JD. Modulation of metabolic syndrome-related inflammation by cocoa. Mol Nutr Food Res. 2013;57(6):948-961. doi:10.1002/mnfr.201200837. – Read More
  22. Cardiac protective effects of Cocoa due to anti-inflammatory actions. Davinelli S, Corbi G, Righetti S, et al. Cardioprotection by Cocoa Polyphenols and ω-3 Fatty Acids: A Disease-Prevention Perspective on Aging-Associated Cardiovascular Risk. J Med Food. 2018;21(10):1060-1069. doi:10.1089/jmf.2018.0002. – Read More
  23. Extract of cacao provided anti-inflammatory effects partly by reducing neutrophil migration. Oyeleke SA, Ajayi AM, Umukoro S, Aderibigbe AO, Ademowo OG. Anti-inflammatory activity of Theobroma cacao L. stem bark ethanol extract and its fractions in experimental models. J Ethnopharmacol. 2018;222:239-248. doi:10.1016/j.jep.2018.04.050. . – Read More
  24. Antioxidant and potential anticancer effects of Cacao. Ebuehi OAT, Anams C, Gbenle OD, Ajagun-Ogunleye MO. Hydro-ethanol seed extract of Theobroma cacao exhibits antioxidant activities and potential anticancer property. J Food Biochem. 2019;43(4):e12767. doi:10.1111/jfbc.12767. – Read More
  25. Anti-inflammatory and anti-neuroinflammatory effects of vanillin. Kim ME, Na JY, Park YD, Lee JS. Anti-Neuroinflammatory Effects of Vanillin Through the Regulation of Inflammatory Factors and NF-κB Signaling in LPS-Stimulated Microglia. Appl Biochem Biotechnol. 2019;187(3):884-893. doi:10.1007/s12010-018-2857-5. . – Read More
  26. Review for low back pain: Gagnier JJ, Oltean H, van Tulder MW, Berman BM, Bombardier C, Robbins CB. Herbal Medicine for Low Back Pain: A Cochrane Review. Spine (Phila Pa 1976). 2016 Jan;41(2):116-33. doi: 10.1097/BRS.0000000000001310. PMID: 26630428. – Read More
  27. Safety: Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin. Int J Toxicol. 2007;26 Suppl 1:3-106. doi: 10.1080/10915810601163939. PMID: 17365137. – Read More
  28. Pain/inflammation: Karami S, Shamshiri S, Abdollahi M, Rahimi R. An evidence-based review of medicinal plants used in traditional Persian medicine for treatment of osteoarthritis. Curr Drug Discov Technol. 2020 Mar 15. doi: 10.2174/1570163817666200316105658. Epub ahead of print. PMID: 32178613. – Read More
  29. Inflammation: An Endocannabinoid Uptake Inhibitor from Black Pepper Exerts Pronounced Anti-Inflammatory Effects in Mice. Reynoso, Ines del Carmen; Najar-Guerrero, Israel; Escareño, Noé; Flores-Soto, Mario Eduardo; Gertsch, Jürg; Viveros-Paredes, Juan Manuel (2017). An Endocannabinoid Uptake Inhibitor from Black Pepper Exerts Pronounced Anti-Inflammatory Effects in Mice. Journal of agricultural and food chemistry, 65(43), pp. 9435-9442. American Chemical Society 10.1021/acs.jafc.7b02979. – Read More
  30. In combo with Curcuma: Chen Z, Sun D, Bi X, Zeng X, Luo W, Cai D, Zeng Q, Xu A. Pharmacokinetic based study on “lagged stimulation” of Curcumae Longae Rhizoma – Piper nigrum couplet in their main active components’ metabolism using UPLC-MS-MS. Phytomedicine. 2017 Apr 15;27:15-22. doi: 10.1016/j.phymed.2017.01.012. Epub 2017 Feb 1. PMID: 28314475. https:// – Read More
  31. www.ncbi.nlm.nih.gov/pubmed/28314475 – Read More
  32. Review: Chavarria D, Silva T, Magalhães e Silva D, Remião F, Borges F. Lessons from black pepper: piperine and derivatives thereof. Expert Opin Ther Pat. 2016;26(2):245-64. doi: 10.1517/13543776.2016.1118057. Epub 2015 Dec 5. PMID: 26560940. – Read More
  33. Analgesic effects: Bukhari IA, Pivac N, Alhumayyd MS, Mahesar AL, Gilani AH. The analgesic and anticonvulsant effects of piperine in mice. J Physiol Pharmacol. 2013 Dec;64(6):789-94. PMID: 24388894. – Read More

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